Uncoupling Hepatic Oxidative Phosphorylation Reduces Tumor Growth in Two Murine Models of Colon Cancer

Obesity is associated with colon cancer pathogenesis, but the underlying mechanism is actively debated. Here, we confirm that diet-induced obesity promotes tumor growth in two murine colon cancer models and show that this effect is reversed by an orally administered controlled-release mitochondrial...

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Опубликовано в: :Cell Rep
Главные авторы: Wang, Yongliang, Nasiri, Ali R., Damsky, William E., Perry, Curtis J., Zhang, Xian-Man, Rabin-Court, Aviva, Pollak, Michael N., Shulman, Gerald I., Perry, Rachel J.
Формат: Artigo
Язык:Inglês
Опубликовано: 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6056247/
https://ncbi.nlm.nih.gov/pubmed/29972790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.06.008
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