Gut Microbiota Produced Tryptamine Activates an Epithelial G-protein Coupled Receptor to Increase Colonic Secretion

Tryptamine, a tryptophan-derived monoamine similar to 5-hydroxytryptamine (5-HT), is produced by gut bacteria and is abundant in human and rodent feces. However, the physiologic effect of tryptamine in the gastrointestinal (GI) tract remains unknown. Here, we show that the biological effects of tryp...

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Publicat a:Cell Host Microbe
Autors principals: Bhattarai, Yogesh, Williams, Brianna B., Battaglioli, Eric J., Whitaker, Weston R., Till, Lisa, Grover, Madhusudan, Linden, David R., Akiba, Yasutada, Kandimalla, Karunya K., Zachos, Nicholas C., Kaunitz, Jonathan D., Sonnenburg, Justin L., Fischbach, Michael A., Farrugia, Gianrico, Kashyap, Purna C.
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6055526/
https://ncbi.nlm.nih.gov/pubmed/29902441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2018.05.004
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