Bacterially Derived Tryptamine Increases Mucus Release by Activating a Host Receptor in a Mouse Model of Inflammatory Bowel Disease

Recent studies emphasize the role of microbial metabolites in regulating gastrointestinal (GI) physiology through activation of host receptors, highlighting the potential for inter-kingdom signaling in treating GI disorders. In this study, we show that tryptamine, a tryptophan-derived bacterial meta...

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Detalhes bibliográficos
Publicado no:iScience
Main Authors: Bhattarai, Yogesh, Jie, Si, Linden, David R., Ghatak, Sayak, Mars, Ruben A.T., Williams, Brianna B., Pu, Meng, Sonnenburg, Justin L., Fischbach, Michael A., Farrugia, Gianrico, Sha, Lei, Kashyap, Purna C.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7702010/
https://ncbi.nlm.nih.gov/pubmed/33299969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101798
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