Gut Microbiota Produced Tryptamine Activates an Epithelial G-protein Coupled Receptor to Increase Colonic Secretion

Tryptamine, a tryptophan-derived monoamine similar to 5-hydroxytryptamine (5-HT), is produced by gut bacteria and is abundant in human and rodent feces. However, the physiologic effect of tryptamine in the gastrointestinal (GI) tract remains unknown. Here, we show that the biological effects of tryp...

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Detalhes bibliográficos
Publicado no:Cell Host Microbe
Main Authors: Bhattarai, Yogesh, Williams, Brianna B., Battaglioli, Eric J., Whitaker, Weston R., Till, Lisa, Grover, Madhusudan, Linden, David R., Akiba, Yasutada, Kandimalla, Karunya K., Zachos, Nicholas C., Kaunitz, Jonathan D., Sonnenburg, Justin L., Fischbach, Michael A., Farrugia, Gianrico, Kashyap, Purna C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6055526/
https://ncbi.nlm.nih.gov/pubmed/29902441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2018.05.004
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