Gut Microbiota Produced Tryptamine Activates an Epithelial G-protein Coupled Receptor to Increase Colonic Secretion

Tryptamine, a tryptophan-derived monoamine similar to 5-hydroxytryptamine (5-HT), is produced by gut bacteria and is abundant in human and rodent feces. However, the physiologic effect of tryptamine in the gastrointestinal (GI) tract remains unknown. Here, we show that the biological effects of tryp...

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Pubblicato in:Cell Host Microbe
Autori principali: Bhattarai, Yogesh, Williams, Brianna B., Battaglioli, Eric J., Whitaker, Weston R., Till, Lisa, Grover, Madhusudan, Linden, David R., Akiba, Yasutada, Kandimalla, Karunya K., Zachos, Nicholas C., Kaunitz, Jonathan D., Sonnenburg, Justin L., Fischbach, Michael A., Farrugia, Gianrico, Kashyap, Purna C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6055526/
https://ncbi.nlm.nih.gov/pubmed/29902441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2018.05.004
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