Deep sequencing and pathway-focused analysis revealed multigene oncodriver signatures predicting survival outcomes in advanced colorectal cancer

Genomic technologies are reshaping the molecular landscape of colorectal cancer (CRC), revealing that oncogenic driver mutations (APC and TP53) coexist with still underappreciated genetic events. We hypothesized that mutational analysis of CRC-linked genes may provide novel information on the connec...

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Publicado en:Oncogenesis
Main Authors: De Nicola, Francesca, Goeman, Frauke, Pallocca, Matteo, Sperati, Francesca, Pizzuti, Laura, Melucci, Elisa, Casini, Beatrice, Amoreo, Carla Azzurra, Gallo, Enzo, Diodoro, Maria Grazia, Buglioni, Simonetta, Mazzotta, Marco, Vici, Patrizia, Sergi, Domenico, Di Lauro, Luigi, Barba, Maddalena, Pescarmona, Edoardo, Ciliberto, Gennaro, De Maria, Ruggero, Fanciulli, Maurizio, Maugeri-Saccà, Marcello
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6054833/
https://ncbi.nlm.nih.gov/pubmed/30032163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41389-018-0066-2
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