Investigation of the key chemical structures involved in the anticancer activity of disulfiram in A549 non-small cell lung cancer cell line

BACKGROUND: Disulfiram (DS), an antialcoholism medicine, demonstrated strong anticancer activity in the laboratory but did not show promising results in clinical trials. The anticancer activity of DS is copper dependent. The reaction of DS and copper generates reactive oxygen species (ROS). After or...

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Enregistré dans:
Détails bibliographiques
Publié dans:BMC Cancer
Auteurs principaux: Butcher, Kate, Kannappan, Vinodh, Kilari, Rajagopal Sharada, Morris, Mark R., McConville, Christopher, Armesilla, Angel L., Wang, Weiguang
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2018
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6054747/
https://ncbi.nlm.nih.gov/pubmed/30031402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-018-4617-x
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