Investigation of the key chemical structures involved in the anticancer activity of disulfiram in A549 non-small cell lung cancer cell line

BACKGROUND: Disulfiram (DS), an antialcoholism medicine, demonstrated strong anticancer activity in the laboratory but did not show promising results in clinical trials. The anticancer activity of DS is copper dependent. The reaction of DS and copper generates reactive oxygen species (ROS). After or...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Butcher, Kate, Kannappan, Vinodh, Kilari, Rajagopal Sharada, Morris, Mark R., McConville, Christopher, Armesilla, Angel L., Wang, Weiguang
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6054747/
https://ncbi.nlm.nih.gov/pubmed/30031402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-018-4617-x
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