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Efficient Enrichment of Gene-Modified Primary T Cells via CCR5-Targeted Integration of Mutant Dihydrofolate Reductase
Targeted gene therapy strategies utilizing homology-driven repair (HDR) allow for greater control over transgene integration site, copy number, and expression—significant advantages over traditional vector-mediated gene therapy with random genome integration. However, the relatively low efficiency o...
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| Gepubliceerd in: | Mol Ther Methods Clin Dev |
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| Hoofdauteurs: | , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Society of Gene & Cell Therapy
2018
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6054698/ https://ncbi.nlm.nih.gov/pubmed/30038938 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2018.04.002 |
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