Efficient Enrichment of Gene-Modified Primary T Cells via CCR5-Targeted Integration of Mutant Dihydrofolate Reductase

Targeted gene therapy strategies utilizing homology-driven repair (HDR) allow for greater control over transgene integration site, copy number, and expression—significant advantages over traditional vector-mediated gene therapy with random genome integration. However, the relatively low efficiency o...

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Vydáno v:Mol Ther Methods Clin Dev
Hlavní autoři: Paul, Biswajit, Ibarra, Guillermo S. Romano, Hubbard, Nicholas, Einhaus, Teresa, Astrakhan, Alexander, Rawlings, David J., Kiem, Hans-Peter, Peterson, Christopher W.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Gene & Cell Therapy 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6054698/
https://ncbi.nlm.nih.gov/pubmed/30038938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2018.04.002
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