Staurosporine Increases Lentiviral Vector Transduction Efficiency of Human Hematopoietic Stem and Progenitor Cells

Lentiviral vector (LVV)-mediated transduction of human CD34(+) hematopoietic stem and progenitor cells (HSPCs) holds tremendous promise for the treatment of monogenic hematological diseases. This approach requires the generation of a sufficient proportion of gene-modified cells. We identified stauro...

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Detalhes bibliográficos
Publicado no:Mol Ther Methods Clin Dev
Main Authors: Lewis, Gretchen, Christiansen, Lauryn, McKenzie, Jessica, Luo, Min, Pasackow, Eli, Smurnyy, Yegor, Harrington, Sean, Gregory, Philip, Veres, Gabor, Negre, Olivier, Bonner, Melissa
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6054695/
https://ncbi.nlm.nih.gov/pubmed/30038935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2018.04.001
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