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Prostaglandin E(2) Increases Lentiviral Vector Transduction Efficiency of Adult Human Hematopoietic Stem and Progenitor Cells

Gene therapy currently in development for hemoglobinopathies utilizes ex vivo lentiviral transduction of CD34(+) hematopoietic stem and progenitor cells (HSPCs). A small-molecule screen identified prostaglandin E(2) (PGE(2)) as a positive mediator of lentiviral transduction of CD34(+) cells. Supplem...

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Publicado en:Mol Ther
Main Authors: Heffner, Garrett C., Bonner, Melissa, Christiansen, Lauryn, Pierciey, Francis J., Campbell, Dakota, Smurnyy, Yegor, Zhang, Wenliang, Hamel, Amanda, Shaw, Seema, Lewis, Gretchen, Goss, Kendrick A., Garijo, Olivia, Torbett, Bruce E., Horton, Holly, Finer, Mitchell H., Gregory, Philip D., Veres, Gabor
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Gene & Cell Therapy 2018
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5763075/
https://ncbi.nlm.nih.gov/pubmed/29102562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2017.09.025
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