Prostaglandin E(2) Increases Lentiviral Vector Transduction Efficiency of Adult Human Hematopoietic Stem and Progenitor Cells

Gene therapy currently in development for hemoglobinopathies utilizes ex vivo lentiviral transduction of CD34(+) hematopoietic stem and progenitor cells (HSPCs). A small-molecule screen identified prostaglandin E(2) (PGE(2)) as a positive mediator of lentiviral transduction of CD34(+) cells. Supplem...

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Publicado no:Mol Ther
Main Authors: Heffner, Garrett C., Bonner, Melissa, Christiansen, Lauryn, Pierciey, Francis J., Campbell, Dakota, Smurnyy, Yegor, Zhang, Wenliang, Hamel, Amanda, Shaw, Seema, Lewis, Gretchen, Goss, Kendrick A., Garijo, Olivia, Torbett, Bruce E., Horton, Holly, Finer, Mitchell H., Gregory, Philip D., Veres, Gabor
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2018
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5763075/
https://ncbi.nlm.nih.gov/pubmed/29102562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2017.09.025
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