Recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma

Pineoblastoma is a rare and highly aggressive brain cancer of childhood, histologically belonging to the spectrum of primitive neuroectodermal tumors. Patients with germline mutations in DICER1, a ribonuclease involved in microRNA processing, have increased risk of pineoblastoma, but genetic drivers...

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I publikationen:Nat Commun
Huvudupphovsmän: Snuderl, Matija, Kannan, Kasthuri, Pfaff, Elke, Wang, Shiyang, Stafford, James M., Serrano, Jonathan, Heguy, Adriana, Ray, Karina, Faustin, Arline, Aminova, Olga, Dolgalev, Igor, Stapleton, Stacie L., Zagzag, David, Chiriboga, Luis, Gardner, Sharon L., Wisoff, Jeffrey H., Golfinos, John G., Capper, David, Hovestadt, Volker, Rosenblum, Marc K., Placantonakis, Dimitris G., LeBoeuf, Sarah E., Papagiannakopoulos, Thales Y., Chavez, Lukas, Ahsan, Sama, Eberhart, Charles G., Pfister, Stefan M., Jones, David T. W., Karajannis, Matthias A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6054684/
https://ncbi.nlm.nih.gov/pubmed/30030436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05029-3
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