Insights about clonal hematopoiesis from 8,342 mosaic chromosomal alterations

The selective pressures that shape clonal evolution in healthy individuals are largely unknown. Here we investigate 8,342 mosaic chromosomal alterations (mCAs) of length 50kb–249Mb that we uncovered in blood-derived DNA from 151,202 UK Biobank participants using new phase-based computational techniq...

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Vydáno v:Nature
Hlavní autoři: Loh, Po-Ru, Genovese, Giulio, Handsaker, Robert E, Finucane, Hilary K, Reshef, Yakir A, Palamara, Pier Francesco, Birmann, Brenda M, Talkowski, Michael E, Bakhoum, Samuel F, McCarroll, Steven A, Price, Alkes L
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6054542/
https://ncbi.nlm.nih.gov/pubmed/29995854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0321-x
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