Insights about clonal hematopoiesis from 8,342 mosaic chromosomal alterations

The selective pressures that shape clonal evolution in healthy individuals are largely unknown. Here we investigate 8,342 mosaic chromosomal alterations (mCAs) of length 50kb–249Mb that we uncovered in blood-derived DNA from 151,202 UK Biobank participants using new phase-based computational techniq...

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Bibliografske podrobnosti
izdano v:Nature
Main Authors: Loh, Po-Ru, Genovese, Giulio, Handsaker, Robert E, Finucane, Hilary K, Reshef, Yakir A, Palamara, Pier Francesco, Birmann, Brenda M, Talkowski, Michael E, Bakhoum, Samuel F, McCarroll, Steven A, Price, Alkes L
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6054542/
https://ncbi.nlm.nih.gov/pubmed/29995854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0321-x
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