A Novel PRKAR1B-BRAF Fusion in Gastrointestinal Stromal Tumor Guides Adjuvant Treatment Decision-Making During Pregnancy

Gastrointestinal stromal tumors (GISTs) are rare in pregnancy, with only 11 reported cases. Adjuvant imatinib therapy, which targets the most common driver mutations in GIST (KIT and PDGFRA), is recommended for patients with high-risk GIST, but it has known teratogenicity in the first trimester. A 3...

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Udgivet i:J Natl Compr Canc Netw
Main Authors: Charo, Lindsey M., Burgoyne, Adam M., Fanta, Paul T., Patel, Hitendra, Chmielecki, Juliann, Sicklick, Jason K., McHale, Michael T.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6053908/
https://ncbi.nlm.nih.gov/pubmed/29523662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.6004/jnccn.2017.7039
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