FGFR1 and NTRK3 actionable alterations in “Wild-Type” gastrointestinal stromal tumors

BACKGROUND: About 10–15% of adult, and most pediatric, gastrointestinal stromal tumors (GIST) lack mutations in KIT, PDGFRA, SDHx, or RAS pathway components (KRAS, BRAF, NF1). The identification of additional mutated genes in this rare subset of tumors can have important clinical benefit to identify...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Shi, Eileen, Chmielecki, Juliann, Tang, Chih-Min, Wang, Kai, Heinrich, Michael C., Kang, Guhyun, Corless, Christopher L., Hong, David, Fero, Katherine E., Murphy, James D., Fanta, Paul T., Ali, Siraj M., De Siena, Martina, Burgoyne, Adam M., Movva, Sujana, Madlensky, Lisa, Heestand, Gregory M., Trent, Jonathan C., Kurzrock, Razelle, Morosini, Deborah, Ross, Jeffrey S., Harismendy, Olivier, Sicklick, Jason K.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5157084/
https://ncbi.nlm.nih.gov/pubmed/27974047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-016-1075-6
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