Concomitant KIT/BRAF and PDGFRA/BRAF mutations are rare events in gastrointestinal stromal tumors

AIM: The BRAF mutation is a rare pathogenetic alternative to KIT/PDGFRA mutation in GIST and causes Imatinib resistance. A recent description of KIT and BRAF mutations co-occurring in an untreated GIST has challenged the concept of their being mutually exclusive and may account for ab initio resista...

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Detalles Bibliográficos
Publicado en:Oncotarget
Main Authors: Rossi, Sabrina, Sbaraglia, Marta, Dell'Orto, Marta Campo, Gasparotto, Daniela, Cacciatore, Matilde, Boscato, Elena, Carraro, Valentina, Toffolatti, Luisa, Gallina, Giovanna, Niero, Monia, Pilozzi, Emanuela, Mandolesi, Alessandra, Sessa, Fausto, Sonzogni, Aurelio, Mancini, Cristina, Mazzoleni, Guido, Romeo, Salvatore, Maestro, Roberta, Dei Tos, Angelo P.
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2016
Assuntos:
Research Paper: Pathology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5058667/
https://ncbi.nlm.nih.gov/pubmed/27097112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8768
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