Cell surface ectodomain integrity of a subset of functional HIV-1 envelopes is dependent on a conserved hydrophilic domain containing region in their C-terminal tail

BACKGROUND: HIV-1 Env gp160 is cleaved to form gp120 and gp41 and the functional HIV-1 Env is a trimer of non-covalently associated heterodimeric subunits, gp120 and gp41. The cleaved, native, trimeric form of Envs expose only broadly neutralizing antibody (bNAb) epitopes while occluding epitopes ta...

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Detalles Bibliográficos
Publicado en:Retrovirology
Main Authors: Samal, Sweety, Das, Supratik, Boliar, Saikat, Qureshi, Huma, Shrivastava, Tripti, Kumar, Naresh, Goswami, Sandeep, Bansal, Manish, Chakrabarti, Bimal K.
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2018
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Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6053805/
https://ncbi.nlm.nih.gov/pubmed/30029604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-018-0431-4
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