Membrane bound modified form of clade B Env, JRCSF is suitable for immunogen design as it is efficiently cleaved and displays all the broadly neutralizing epitopes including V2 and C2 domain-dependent conformational epitopes

BACKGROUND: Antigenicity of HIV-1 envelope proteins (Envs) of both lab-adapted and primary isolates expressed on the cell surface rarely match with in vitro neutralization of viruses, pseudo-typed with corresponding Envs. Often, both neutralizing and non-neutralizing antibodies bind to Envs expresse...

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Detalhes bibliográficos
Publicado no:Retrovirology
Main Authors: Das, Supratik, Boliar, Saikat, Mitra, Nivedita, Samal, Sweety, Bansal, Manish, Koff, Wayne C., Chakrabarti, Bimal K.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5117575/
https://ncbi.nlm.nih.gov/pubmed/27871328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-016-0312-7
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