An Efficiently Cleaved HIV-1 Clade C Env Selectively Binds to Neutralizing Antibodies

An ideal HIV-1 Env immunogen is expected to mimic the native trimeric conformation for inducing broadly neutralizing antibody responses. The native conformation is dependent on efficient cleavage of HIV-1 Env. The clade B isolate, JRFL Env is efficiently cleaved when expressed on the cell surface. H...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Boliar, Saikat, Das, Supratik, Bansal, Manish, Shukla, Brihaspati N., Patil, Shilpa, Shrivastava, Tripti, Samal, Sweety, Goswami, Sandeep, King, C. Richter, Bhattacharya, Jayanta, Chakrabarti, Bimal K.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4379091/
https://ncbi.nlm.nih.gov/pubmed/25822521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0122443
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