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Structural basis for selective inhibition of human PKG Iα by the balanol-like compound N46
Activation of protein kinase G (PKG) Iα in nociceptive neurons induces long-term hyperexcitability that causes chronic pain. Recently, a derivative of the fungal metabolite balanol, N46, has been reported to inhibit PKG Iα with high potency and selectivity and attenuate thermal hyperalgesia and oste...
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| Izdano u: | J Biol Chem |
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| Glavni autori: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2018
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6052212/ https://ncbi.nlm.nih.gov/pubmed/29769318 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002427 |
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