Structural Basis of Analog Specificity in PKG I and II

Cyclic GMP analogs, 8-Br, 8-pCPT, and PET-cGMP, have been widely used for characterizing cellular functions of cGMP-dependent protein kinase (PKG) I and II isotypes. However, interpreting results obtained using these analogs has been difficult due to their low isotype specificity. Additionally, each...

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Vydáno v:ACS Chem Biol
Hlavní autoři: Campbell, James C., Henning, Philipp, Franz, Eugen, Sankaran, Banumathi, Herberg, Friedrich W., Kim, Choel
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5896746/
https://ncbi.nlm.nih.gov/pubmed/28793191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.7b00369
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