The Current State and Future of CRISPR-Cas9 gRNA Design Tools

Recent years have seen the development of computational tools to assist researchers in performing CRISPR-Cas9 experiment optimally. More specifically, these tools aim to maximize on-target activity (guide efficiency) while also minimizing potential off-target effects (guide specificity) by analyzing...

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Publicat a:Front Pharmacol
Autors principals: Wilson, Laurence O. W., O’Brien, Aidan R., Bauer, Denis C.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2018
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6052051/
https://ncbi.nlm.nih.gov/pubmed/30050439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00749
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