Highly multiplexed genome engineering using CRISPR/Cas9 gRNA arrays

The CRISPR/Cas9 system is an RNA guided nuclease system that evolved as a mechanism of adaptive immunity in bacteria. This system has been adopted for numerous genome engineering applications in research and recently, therapeutics. The CRISPR/Cas9 system has been largely implemented by delivery of C...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Kurata, Morito, Wolf, Natalie K., Lahr, Walker S., Weg, Madison T., Kluesner, Mitchell G., Lee, Samantha, Hui, Kai, Shiraiwa, Masano, Webber, Beau R., Moriarity, Branden S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6141065/
https://ncbi.nlm.nih.gov/pubmed/30222773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0198714
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