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Automated Removal of Phospholipids from Membrane Proteins for H/D Exchange Mass Spectrometry Workflows

Membrane proteins are currently the most common targets for pharmaceuticals. However, characterization of their structural dynamics by hydrogen/deuterium exchange mass spectrometry (HDX-MS) is sparse due to insufficient automated methods to handle full-length membrane proteins in lipid bilayers. Add...

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Detalhes bibliográficos
Publicado no:Anal Chem
Main Authors: Anderson, Kyle W., Gallagher, Elyssia S., Hudgens, Jeffrey W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6050989/
https://ncbi.nlm.nih.gov/pubmed/29723469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.8b00429
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