Conformational Changes in Active and Inactive States of Human PP2Cα Characterized by Hydrogen/Deuterium Exchange–Mass Spectrometry

PPM serine/threonine protein phosphatases function in signaling pathways and require millimolar concentrations of Mn(2+) or Mg(2+) ions for activity. Whereas the crystal structure of human PP2Cα displayed two tightly bound Mn(2+) ions in the active site, recent investigations of PPM phosphatases hav...

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Publicado en:Biochemistry
Autores principales: Mazur, Sharlyn J., Gallagher, Elyssia S., Debnath, Subrata, Durell, Stewart R., Anderson, Kyle W., Miller Jenkins, Lisa M., Appella, Ettore, Hudgens, Jeffrey W.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5593270/
https://ncbi.nlm.nih.gov/pubmed/28481111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b01220
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