PBX3/MEK/ERK1/2/LIN28/let-7b positive feedback loop enhances mesenchymal phenotype to promote glioblastoma migration and invasion

BACKGROUND: Brain invasion by glioblastoma (GBM) determines recurrence and prognosis in patients, which is, in part, attributed to increased mesenchymal transition. Here, we report evidence favoring such a role for the Pre-B-cell leukemia homebox (PBX) family member PBX3. METHODS: Western blot, immu...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Xu, Xiupeng, Bao, Zhongyuan, Liu, Yinlong, Jiang, Kuan, Zhi, Tongle, Wang, Dong, Fan, Liang, Liu, Ning, Ji, Jing
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6050701/
https://ncbi.nlm.nih.gov/pubmed/30016974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0841-0
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