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Chiral Brønsted acid-catalyzed intramolecular S(N)2′ reaction for enantioselective construction of a quaternary stereogenic center

An enantioselective intramolecular anti-S(N)2′ cyclization reaction for the construction of a quaternary stereogenic center was accomplished through the activation of the leaving group using a binaphthol-derived phosphoramide as the chiral Brønsted acid catalyst. The present allylic substitution rea...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Shimizu, Masahiro, Kikuchi, Jun, Kondoh, Azusa, Terada, Masahiro
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6050593/
https://ncbi.nlm.nih.gov/pubmed/30079184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc01942h
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