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F(10)BINOL-derived chiral phosphoric acid-catalyzed enantioselective carbonyl-ene reaction: theoretical elucidation of stereochemical outcomes

An F(10)BINOL-derived chiral phosphoric acid was shown to be an effective catalyst for an enantioselective carbonyl-ene reaction of 1,1-disubstituted olefins with ethyl glyoxylate as the common enophile. The perfluoro-binaphthyl skeleton is beneficial not only for adopting high catalytic activity bu...

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Bibliografiske detaljer
Udgivet i:Chem Sci
Main Authors: Kikuchi, Jun, Aramaki, Hiromu, Okamoto, Hiroshi, Terada, Masahiro
Format: Artigo
Sprog:Inglês
Udgivet: Royal Society of Chemistry 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6354837/
https://ncbi.nlm.nih.gov/pubmed/30809359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc03587c
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