Indoleamine 2,3-Dioxygenase Expression Pattern in the Tumor Microenvironment Predicts Clinical Outcome in Early Stage Cervical Cancer

The indoleamine 2,3-dioxygenase (IDO) enzyme can act as an immunoregulator by inhibiting T cell function via the degradation of the essential amino acid tryptophan (trp) into kynurenine (kyn) and its derivates. The kyn/trp ratio in serum is a prognostic factor for cervical cancer patients; however,...

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Enregistré dans:
Détails bibliographiques
Publié dans:Front Immunol
Auteurs principaux: Heeren, A. Marijne, van Dijk, Ilse, Berry, Daniella R. A. I., Khelil, Maryam, Ferns, Debbie, Kole, Jeroen, Musters, René J. P., Thijssen, Victor L., Mom, Constantijne H., Kenter, Gemma G., Bleeker, Maaike C. G., de Gruijl, Tanja D., Jordanova, Ekaterina S.
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2018
Sujets:
Immunology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6050387/
https://ncbi.nlm.nih.gov/pubmed/30050535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01598
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