Indoleamine 2,3-Dioxygenase Expression Pattern in the Tumor Microenvironment Predicts Clinical Outcome in Early Stage Cervical Cancer

The indoleamine 2,3-dioxygenase (IDO) enzyme can act as an immunoregulator by inhibiting T cell function via the degradation of the essential amino acid tryptophan (trp) into kynurenine (kyn) and its derivates. The kyn/trp ratio in serum is a prognostic factor for cervical cancer patients; however,...

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Veröffentlicht in:Front Immunol
Hauptverfasser: Heeren, A. Marijne, van Dijk, Ilse, Berry, Daniella R. A. I., Khelil, Maryam, Ferns, Debbie, Kole, Jeroen, Musters, René J. P., Thijssen, Victor L., Mom, Constantijne H., Kenter, Gemma G., Bleeker, Maaike C. G., de Gruijl, Tanja D., Jordanova, Ekaterina S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6050387/
https://ncbi.nlm.nih.gov/pubmed/30050535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01598
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