Indoleamine 2,3-Dioxygenase Expression Pattern in the Tumor Microenvironment Predicts Clinical Outcome in Early Stage Cervical Cancer

The indoleamine 2,3-dioxygenase (IDO) enzyme can act as an immunoregulator by inhibiting T cell function via the degradation of the essential amino acid tryptophan (trp) into kynurenine (kyn) and its derivates. The kyn/trp ratio in serum is a prognostic factor for cervical cancer patients; however,...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Heeren, A. Marijne, van Dijk, Ilse, Berry, Daniella R. A. I., Khelil, Maryam, Ferns, Debbie, Kole, Jeroen, Musters, René J. P., Thijssen, Victor L., Mom, Constantijne H., Kenter, Gemma G., Bleeker, Maaike C. G., de Gruijl, Tanja D., Jordanova, Ekaterina S.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6050387/
https://ncbi.nlm.nih.gov/pubmed/30050535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01598
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