Nodal metastasis in cervical cancer occurs in clearly delineated fields of immune suppression in the pelvic lymph catchment area

In cervical cancer, high frequencies of regulatory T cells (Tregs) and immunosuppressive PD-L1(+)CD14(+) antigen-presenting cells dominate the microenvironment of tumor-positive lymph nodes (LN+). It is unknown whether this is restricted to LN+ or precedes metastasis, emanating from the primary tumo...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Heeren, A. Marijne, de Boer, Eline, Bleeker, Maaike C.G., Musters, René J.P., Buist, Marrije R., Kenter, Gemma G., de Gruijl, Tanja D., Jordanova, Ekaterina S.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper: Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741707/
https://ncbi.nlm.nih.gov/pubmed/26431490
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