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Effects of Mg(2+) on recovery of NMDA receptors from inhibition by memantine and ketamine reveal properties of a second site
Memantine and ketamine are NMDA receptor (NMDAR) open channel blockers that are thought to act via similar mechanisms at NMDARs, but exhibit divergent clinical effects. Both drugs act by entering open NMDARs and binding at a site deep within the ion channel (the deep site) at which the endogenous NM...
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| Udgivet i: | Neuropharmacology |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6050087/ https://ncbi.nlm.nih.gov/pubmed/29793153 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2018.05.017 |
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