KLF5 controls glutathione metabolism to suppress p190-BCR-ABL+ B-cell lymphoblastic leukemia

High-risk B-cell acute lymphoblastic leukemia (B-ALL) remains a therapeutic challenge despite advances in the use of tyrosine kinase inhibitors and chimeric-antigen-receptor engineered T cells. Lymphoblastic-leukemia precursors are highly sensitive to oxidative stress. KLF5 is a member of the Krüppe...

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Detalles Bibliográficos
Publicado en:Oncotarget
Main Authors: Zhang, Cuiping, D'Alessandro, Angelo, Wellendorf, Ashley M., Mohmoud, Fatima, Serrano-Lopez, Juana, Perentesis, John P., Komurov, Kakajan, Alexe, Gabriela, Stegmaier, Kimberly, Whitsett, Jeffrey A., Grimes, H. Leighton, Cancelas, Jose A.
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2018
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6049869/
https://ncbi.nlm.nih.gov/pubmed/30038712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25667
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