Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival

Despite the introduction of tyrosine kinase inhibitor therapy, the prognosis for p190-BCR-ABL(+) acute lymphoblastic leukemia remains poor. In the present study, we present the cellular and molecular roles of the Rho GTPase guanine nucleotide exchange factor Vav in lymphoid leukemogenesis and explor...

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Autors principals: Chang, Kyung Hee, Sanchez-Aguilera, Abel, Shen, Shuhong, Sengupta, Amitava, Madhu, Malav N., Ficker, Ashley M., Dunn, Susan K., Kuenzi, Ashley M., Arnett, Jorden L., Santho, Rebecca A., Agirre, Xabier, Perentesis, John P., Deininger, Michael W., Zheng, Yi, Bustelo, Xose R., Williams, David A., Cancelas, Jose A.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2012
Matèries:
Lymphoid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412345/
https://ncbi.nlm.nih.gov/pubmed/22692505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-06-361709
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