Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival

Despite the introduction of tyrosine kinase inhibitor therapy, the prognosis for p190-BCR-ABL(+) acute lymphoblastic leukemia remains poor. In the present study, we present the cellular and molecular roles of the Rho GTPase guanine nucleotide exchange factor Vav in lymphoid leukemogenesis and explor...

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Detalhes bibliográficos
Main Authors: Chang, Kyung Hee, Sanchez-Aguilera, Abel, Shen, Shuhong, Sengupta, Amitava, Madhu, Malav N., Ficker, Ashley M., Dunn, Susan K., Kuenzi, Ashley M., Arnett, Jorden L., Santho, Rebecca A., Agirre, Xabier, Perentesis, John P., Deininger, Michael W., Zheng, Yi, Bustelo, Xose R., Williams, David A., Cancelas, Jose A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412345/
https://ncbi.nlm.nih.gov/pubmed/22692505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-06-361709
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