Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival

Despite the introduction of tyrosine kinase inhibitor therapy, the prognosis for p190-BCR-ABL(+) acute lymphoblastic leukemia remains poor. In the present study, we present the cellular and molecular roles of the Rho GTPase guanine nucleotide exchange factor Vav in lymphoid leukemogenesis and explor...

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Détails bibliographiques
Auteurs principaux: Chang, Kyung Hee, Sanchez-Aguilera, Abel, Shen, Shuhong, Sengupta, Amitava, Madhu, Malav N., Ficker, Ashley M., Dunn, Susan K., Kuenzi, Ashley M., Arnett, Jorden L., Santho, Rebecca A., Agirre, Xabier, Perentesis, John P., Deininger, Michael W., Zheng, Yi, Bustelo, Xose R., Williams, David A., Cancelas, Jose A.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2012
Sujets:
Lymphoid Neoplasia
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412345/
https://ncbi.nlm.nih.gov/pubmed/22692505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-06-361709
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