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Rac2 GTPase deficiency depletes BCR-ABL(+) leukemic stem cells and progenitors in vivo
Chronic myelogenous leukemia (CML) is a clonal myeloproliferative disease (MPD) initiated by p210-BCR-ABL–mediated transformation of hematopoietic stem cells (HSCs). Inhibition of the ABL kinase alone is not sufficient to eradicate leukemic stem cells (LSCs). We have previously shown that the defici...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2904584/ https://ncbi.nlm.nih.gov/pubmed/20407032 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-10-247437 |
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