Nilotinib treatment in mouse models of P190 Bcr/Abl lymphoblastic leukemia

BACKGROUND: Ph-positive leukemias are caused by the aberrant fusion of the BCR and ABL genes. Nilotinib is a selective Bcr/Abl tyrosine kinase inhibitor related to imatinib, which is widely used to treat chronic myelogenous leukemia. Because Ph-positive acute lymphoblastic leukemia only responds tra...

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Autores principales: Kaur, Pavinder, Feldhahn, Niklas, Zhang, Bin, Trageser, Daniel, Müschen, Markus, Pertz, Veerle, Groffen, John, Heisterkamp, Nora
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2007
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2169263/
https://ncbi.nlm.nih.gov/pubmed/17958915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-6-67
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