Environment-mediated drug resistance in Bcr/Abl-positive acute lymphoblastic leukemia

Although cure rates for acute lymphoblastic leukemia (ALL) have increased, development of resistance to drugs and patient relapse are common. The environment in which the leukemia cells are present during the drug treatment is known to provide significant survival benefit. Here, we have modeled this...

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Main Authors: Feldhahn, Niklas, Arutyunyan, Anna, Stoddart, Sonia, Zhang, Bin, Schmidhuber, Sabine, Yi, Sun-Ju, Kim, Yong-mi, Groffen, John, Heisterkamp, Nora
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2012
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3429566/
https://ncbi.nlm.nih.gov/pubmed/22934254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.20249
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