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Resistance to farnesyltransferase inhibitors in Bcr/Abl-positive lymphoblastic leukemia by increased expression of a novel ABC transporter homolog ATP11a

Resistance to cytotoxic drugs frequently emerges during treatment of leukemia with conventional chemotherapy. New classes of anticancer drugs, such as the farnesyltransferase inhibitors (FTIs), show therapeutic promise, but whether cells will easily develop resistance against them is not known. Here...

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Autors principals: Zhang, Bin, Groffen, John, Heisterkamp, Nora
Format: Artigo
Idioma:Inglês
Publicat: The American Society of Hematology 2005
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895195/
https://ncbi.nlm.nih.gov/pubmed/15860663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-09-3655
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