Generation of rac3 Null Mutant Mice: Role of Rac3 in Bcr/Abl-Caused Lymphoblastic Leukemia

Numerous studies indirectly implicate Rac GTPases in cancer. To investigate if Rac3 contributes to normal or malignant cell function, we generated rac3 null mutants through gene targeting. These mice were viable, fertile, and lacked an obvious external phenotype. This shows Rac3 function is dispensa...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Cho, Young Jin, Zhang, Bin, Kaartinen, Vesa, Haataja, Leena, de Curtis, Ivan, Groffen, John, Heisterkamp, Nora
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2005
Sujets:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1157002/
https://ncbi.nlm.nih.gov/pubmed/15964830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.13.5777-5785.2005
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires