Generation of rac3 Null Mutant Mice: Role of Rac3 in Bcr/Abl-Caused Lymphoblastic Leukemia

Numerous studies indirectly implicate Rac GTPases in cancer. To investigate if Rac3 contributes to normal or malignant cell function, we generated rac3 null mutants through gene targeting. These mice were viable, fertile, and lacked an obvious external phenotype. This shows Rac3 function is dispensa...

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Detalhes bibliográficos
Main Authors: Cho, Young Jin, Zhang, Bin, Kaartinen, Vesa, Haataja, Leena, de Curtis, Ivan, Groffen, John, Heisterkamp, Nora
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1157002/
https://ncbi.nlm.nih.gov/pubmed/15964830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.13.5777-5785.2005
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