lncRNA PAPAS tethered to the rDNA enhancer recruits hypophosphorylated CHD4/NuRD to repress rRNA synthesis at elevated temperatures

Attenuation of pre-rRNA synthesis in response to elevated temperature is accompanied by increased levels of PAPAS (“promoter and pre-rRNA antisense”), a long noncoding RNA (lncRNA) that is transcribed in an orientation antisense to pre-rRNA. Here we show that PAPAS interacts directly with DNA, formi...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Genes Dev
Main Authors: Zhao, Zhongliang, Sentürk, Nevcin, Song, Chenlin, Grummt, Ingrid
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2018
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6049515/
https://ncbi.nlm.nih.gov/pubmed/29907651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.311688.118
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