Loss of cerebellar glutamate transporters EAAT4 and GLAST differentially affects the spontaneous firing pattern and survival of Purkinje cells

Loss of excitatory amino acid transporters (EAATs) has been implicated in a number of human diseases including spinocerebellar ataxias, Alzhiemer’s disease and motor neuron disease. EAAT4 and GLAST/EAAT1 are the two predominant EAATs responsible for maintaining low extracellular glutamate levels and...

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Publicado en:Hum Mol Genet
Autores principales: Perkins, Emma M, Clarkson, Yvonne L, Suminaite, Daumante, Lyndon, Alastair R, Tanaka, Kohichi, Rothstein, Jeffrey D, Skehel, Paul A, Wyllie, David J A, Jackson, Mandy
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2018
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6049029/
https://ncbi.nlm.nih.gov/pubmed/29741614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy169
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