β-III spectrin underpins ankyrin R function in Purkinje cell dendritic trees: protein complex critical for sodium channel activity is impaired by SCA5-associated mutations

Beta III spectrin is present throughout the elaborate dendritic tree of cerebellar Purkinje cells and is required for normal neuronal morphology and cell survival. Spinocerebellar ataxia type 5 (SCA5) and spectrin associated autosomal recessive cerebellar ataxia type 1 are human neurodegenerative di...

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Autores principales: Clarkson, Yvonne L., Perkins, Emma M., Cairncross, Callum J., Lyndon, Alastair R., Skehel, Paul A., Jackson, Mandy
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2014
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4065159/
https://ncbi.nlm.nih.gov/pubmed/24603075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu103
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