β-III Spectrin Is Critical for Development of Purkinje Cell Dendritic Tree and Spine Morphogenesis

Mutations in the gene encoding β-III spectrin give rise to spinocerebellar ataxia type 5, a neurodegenerative disease characterized by progressive thinning of the molecular layer, loss of Purkinje cells and increasing motor deficits. A mouse lacking full-length β-III spectrin (β-III(−/−)) displays a...

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Detalhes bibliográficos
Main Authors: Gao, Yuanzheng, Perkins, Emma M., Clarkson, Yvonne L., Tobia, Steven, Lyndon, Alastair R., Jackson, Mandy, Rothstein, Jeffrey D.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3374928/
https://ncbi.nlm.nih.gov/pubmed/22090485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3332-11.2011
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