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In vitro–transcribed guide RNAs trigger an innate immune response via the RIG-I pathway
Clustered, regularly interspaced, short palindromic repeat (CRISPR)–CRISPR-associated 9 (Cas9) genome editing is revolutionizing fundamental research and has great potential for the treatment of many diseases. While editing of immortalized cell lines has become relatively easy, editing of therapeuti...
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| Publicado no: | PLoS Biol |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6049001/ https://ncbi.nlm.nih.gov/pubmed/30011268 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2005840 |
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