RNAs Containing Modified Nucleotides Fail To Trigger RIG-I Conformational Changes for Innate Immune Signaling

Invading pathogen nucleic acids are recognized and bound by cytoplasmic (retinoic acid-inducible gene I [RIG-I]-like) and membrane-bound (Toll-like) pattern recognition receptors to activate innate immune signaling. Modified nucleotides, when present in RNA molecules, diminish the magnitude of these...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Durbin, Ann Fiegen, Wang, Chen, Marcotrigiano, Joseph, Gehrke, Lee
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5030355/
https://ncbi.nlm.nih.gov/pubmed/27651356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00833-16
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