CRISPR RNAs trigger innate immune responses in human cells

Here, we report that CRISPR guide RNAs (gRNAs) with a 5′-triphosphate group (5′-ppp gRNAs) produced via in vitro transcription trigger RNA-sensing innate immune responses in human and murine cells, leading to cytotoxicity. 5′-ppp gRNAs in the cytosol are recognized by DDX58, which in turn activates...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Genome Res
Egile Nagusiak: Kim, Sojung, Koo, Taeyoung, Jee, Hyeon-Gun, Cho, Hee-Yeon, Lee, Gyeorae, Lim, Dong-Gyun, Shin, Hyoung Shik, Kim, Jin-Soo
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Cold Spring Harbor Laboratory Press 2018
Gaiak:
Method
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5848615/
https://ncbi.nlm.nih.gov/pubmed/29472270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.231936.117
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak