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CRISPR-LbCpf1 prevents choroidal neovascularization in a mouse model of age-related macular degeneration
LbCpf1, derived from Lachnospiraceae bacterium ND2006, is a CRISPR RNA-guided endonuclease and holds promise for therapeutic applications. Here we show that LbCpf1 can be used for therapeutic gene editing in a mouse model of age-related macular degeneration (AMD). The intravitreal delivery of LbCpf1...
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| Publié dans: | Nat Commun |
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| Auteurs principaux: | , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group UK
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5945874/ https://ncbi.nlm.nih.gov/pubmed/29748595 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04175-y |
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