CRISPR-LbCpf1 prevents choroidal neovascularization in a mouse model of age-related macular degeneration

LbCpf1, derived from Lachnospiraceae bacterium ND2006, is a CRISPR RNA-guided endonuclease and holds promise for therapeutic applications. Here we show that LbCpf1 can be used for therapeutic gene editing in a mouse model of age-related macular degeneration (AMD). The intravitreal delivery of LbCpf1...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Koo, Taeyoung, Park, Sung Wook, Jo, Dong Hyun, Kim, Daesik, Kim, Jin Hyoung, Cho, Hee-Yeon, Kim, Jeungeun, Kim, Jeong Hun, Kim, Jin-Soo
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5945874/
https://ncbi.nlm.nih.gov/pubmed/29748595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04175-y
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