The helicase domain of Polθ counteracts RPA to promote alt-NHEJ

Mammalian polymerase theta (Polθ) is a multifunctional enzyme that promotes error-prone DNA repair by alternative-NHEJ (alt-NHEJ). Here we perform structure-function analyses and report that, in addition to the polymerase domain, the helicase activity plays a central role during Polθ-mediated double...

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Gepubliceerd in:Nat Struct Mol Biol
Hoofdauteurs: Mateos-Gomez, Pedro A., Kent, Tatiana, Deng, Sarah K., McDevitt, Shane, Kashkina, Ekaterina, Hoang, Trung M., Pomerantz, Richard T, Sfeir, Agnel
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6047744/
https://ncbi.nlm.nih.gov/pubmed/29058711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3494
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